Hopkinsville is a home rule-class city in and the county seat of Christian County, Kentucky, United States. The population at the 2020 census …Hopkinsville is a home rule-class city in and the county seat of Christian County, Kentucky, United States. The population at the 2020 census was 31,180. The area of present-day Hopkinsville was initially claimed in 1796 by Bartholomew Wood as part of a 1,200-acre grant for his service in the American Revolution. He and his wife Martha Ann moved from Jonesborough, Tennessee, first to a cabin near present-day W. Seventh and Bethel streets; then to a second cabin near present-day 9th and Virginia streets; and finally to a third home near 14th and Campbell.