HIV-1 remodels the spatial organization of its co-receptor, CXCR4, on T cell membranes, showing that viral entry requires receptor clustering rather than simple receptor binding.
Complete disruption of the CXCR4 chemokine receptor gene is embryologically lethal in mice, 11, 12 impeding direct study of CXCR4-mediated tumor progression and metastasis. Current approaches to study ...
Increasing evidence indicates that the tumor microenvironment has critical roles in all aspects of cancer biology, including growth, angiogenesis, metastasis and progression. Although chemokines and ...
WHIM syndrome (characterized by warts, hypogammaglobulinemia, infections, and myelokathexis) is a rare immunodeficiency caused by inherited autosomal-dominant mutations in CXCR4 that confer gain of ...
Immune cells play a key role during pregnancy, adjusting immune system response in a way that enables the fetus to develop while also protecting the parent and fetus from outside assaults like viruses ...
The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...
Effect of adjuvant treatment on the circulating CK-19 mRNA-positive tumor cells in patients with early stage breast cancer This is an ASCO Meeting Abstract from the 2006 ASCO Annual Meeting. This ...
IND submitted to initiate Phase 3 PANDA diagnostic trial in the U.S. in hypertension with underlying primary ...
KG 4/2015: A randomized, controlled, multicenter, open-label phase III clinical trial of GV1001 with gemcitabine/capecitabine in previous untreated, eotaxin-high ...
Patients in the US with the ultra-rare disease WHIM syndrome now have their first approved treatment, after X4 Pharma’s Xolremdi was given a green light by the FDA. Oral CXCR4 antagonist Xolremdi ...
Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell Claudia ...
ALX40-4C NPS Allelix Terminated (Phase I/II) HIV No apparent effect was observed on viral load AMD3100 AnorMED Terminated (Phase I/II) HIV Little effect was observed on viral load AMD3100 (plerixafor) ...
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