Colchicine may be used with caution to manage flare-ups of crystal-induced arthritis among patients with severe chronic kidney disease, with dosage modifications and careful monitoring required.

Probenecid (Benemid) is a uricosuric agent that inhibits the reabsorption of uric acid in proximal tubules of the kidney. 36 Pharmacologic therapy typically begins at 500 mg b.i.d. and gradually ...

October 2, 2012 — New gout guidelines from the American College of Rheumatology are meant to improve gout management by providing clinicians with clear, readily implemented guidance on urate-lowering ...

(Boston)—Gout is the most common form of inflammatory arthritis, with worldwide prevalence of approximately four%. The accumulation of monosodium urate crystals in gout leads to the clinical ...

Colchicine use was linked to a 12% reduction in the risk for total joint arthroplasty among patients with gout. Colchicine use is associated with a modest reduction in the long-term risk for total ...

A large price increase for colchicine in 2010 led to a significant falloff in its use for gout that persisted for the next decade while emergency and rheumatology visits for gout rose, suggesting ...

Over the years, gout has grown in clinical complexity. We see many more cases with iatrogenic factors, multiple comorbidities, advanced age and treatment-refractory hyperuricemia and arthritis (Table ...

Gout sounds like a disease that shouldn’t exist anymore, especially since it’s referred to as the “disease of kings” because of its connection to royal leaders like Henry VIII, who lived with the ...