Learn why cytotoxicity test failures are common in medical devices and discover systematic approaches to identify root causes ...

Measuring the potentially adverse effects of a substance upon an organism is vital for medical science and several industries. One property of a substance that must be known is its cytotoxic effect.

The detrimental effects caused by substances or environmental changes on cell health are described as cytotoxicity. When cells are exposed to a cytotoxic stimulus, their metabolic activity may be ...

Assessment of circulating tumor cell (CTC) patterns among disease-free breast cancer patients vaccinated with a preventive HER2/neu E75-peptide vaccine No significant financial relationships to ...

Previous studies have suggested that austocystin D is oxidized by cytochrome P450 (CYP) oxygenases which then induces DNA damage and suppresses cell proliferation. In this study, we showed that CYP2J2 ...

A phase 1/2 study of the safety, tolerability, and preliminary efficacy of the anti-GITR monoclonal antibody, INCAGN01876, combined with immunotherapies (IO) in patients (Pts) with advanced cancers.

ADCs combine antibodies with drug payloads for targeted therapy, but complex manufacturing requires monitoring CQAs across multiple entities.