Throughout human history, natural products have been the foundation for the discovery and development of therapeutics used to treat diseases ranging from cardiovascular disease to cancer. Their ...

The isoprenoid biosynthesis pathway represents a critical vulnerability in many bacterial and protozoan pathogens owing to its absence in humans. Pathogens such as Plasmodium falciparum, Mycobacterium ...

From medicine to fragrances, nature provides many of the key chemical compounds needed in an endless number of pharmaceuticals and consumer products. Now, a cutting-edge technique engineered by ...

It takes dozens of chemical reactions for a cell to make isoprenoids, a diverse class of molecules found in every type of living organism. Cholesterol, for example, an important component of the ...

There has been considerable excitement generated by findings that statins, which lower plasma cholesterol, may help protect against Alzheimer disease (see Wolozin et al., 2000, Jick et al., 2000, and ...