Neprilysin is a ubiquitous zinc-dependent endopeptidase that regulates the homeostasis of key vasoactive peptides, notably natriuretic peptides, bradykinin and adrenomedullin. By cleaving these ...

A therapy developed by the Swiss-based pharmaceutical company Novartis could be the next big thing for congestive heart failure, a serious disease that afflicts about 5 million Americans. Called ...

Barcelona, Spain – 26 Aug 2022: Sacubitril/valsartan does not change cognitive function, compared with valsartan, in patients with heart failure and mildly reduced or preserved ejection fraction, ...

Heart failure patients are more likely to develop dementia Sacubitril/valsartan, a standard treatment for those with heart failure and previously suspected to exacerbate cognitive impairment, shows no ...

Neprilysin is responsible for the degradation of several vasoactive peptides including atrial and brain natriuretic peptides (NPs) (ANP and BNP). 7 These peptides block the negative cardiovascular ...

The blood-brain barrier border protects the brain by regulating the flow of molecules, peptides, and cells, but it also keeps out many therapeutics. Now, researchers have harnessed the power of a ...

Dr. Edward Dempsey and colleagues of the University of Colorado observed that neprilysin protects against PHTN. Patients with pulmonary hypertension, an increase in pressure in blood vessels in the ...