Gametocytes are the sexual forms of Plasmodium falciparum that enable transmission from humans to mosquitoes. Unlike asexual blood stages, mature gametocytes sequester in tissues and exhibit reduced ...

Interaction between LFA-1 on natural killer cells and GBP-130 on infected erythrocytes enables immune recognition and killing of Plasmodium falciparum-infected red blood cells.

Plasmodium falciparum, the most lethal human malaria parasite, undergoes complex metabolic reprogramming to thrive within hepatocytes and erythrocytes. During liver‐stage development the parasite ...

Researchers at Weill Cornell Medicine have discovered how Plasmodium falciparum, the parasite that causes malaria when transmitted through a mosquito bite, can hide from the body’s immune system, ...

New data published in The Journal of Immunology uncovered the role of Plasmodium falciparum infection (malaria) in the development of Burkitt lymphoma (BL), the most common childhood cancer in ...

CIS43LS is a monoclonal antibody that was shown to protect against controlled Plasmodium falciparum infection in a phase 1 clinical trial. Whether a monoclonal antibody can prevent P. falciparum ...

Cerebral malaria kills 1 out of 5 children that suffer from it, and causes long-term disabilities in half of the survivors. Malaria is caused by the parasite Plasmodium falciparum, which reproduces in ...

All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A ...

A gene called PfAP2-HS allows the malaria parasite to defend itself from adverse conditions in the host, including febrile temperatures, according to new research. The study resolves a long-standing ...

In a report published on March 21, 2024 in EMBO Molecular Medicine (A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion) investigators at Seattle ...