A METHOD was recently developed in this laboratory by which it was possible to degrade DNA chemically to sequences of purine nucleotides 1,2. During this procedure the DNA is first freed of ...

Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...

A new study has found a molecule hailed as a potential drug candidate for Parkinson's disease is no longer an effective therapeutic option. The WEHI-led research has debunked over 10 years of research ...

Nucleotides are the fundamental units that make up the genetic material of all living organisms. They are the building blocks of DNA and RNA, which store and transmit genetic information. Nucleotides ...

Blocking brain damage triggered by a glioblastoma, an aggressive brain cancer, may slow the growth of the cancer and allow the brain to keep working better for longer, according to a new study led by ...