In the hemodialysis population, cardiovascular calcifications result from excess phosphate and calcium, as well as reduced activity of inhibitors of calcification, such as matrix Gla protein. Vitamin ...

Chronic kidney disease (CKD) is a progressive condition marked by declining renal function, which predisposes patients to systemic metabolic imbalances. A prominent complication in CKD is vascular ...

Renal transplantation does not stop or reverse coronary artery calcification (CAC), according to researchers. In a study that included 150 renal transplant recipients, CAC prevalence increased from 35 ...

Patients who form calcium kidney stones are more likely to have higher abdominal aortic calcification (AAC) and lower vertebral bone mineral density (BMD) scores than those who do not develop kidney ...

Researchers from Tokyo Medical and Dental University (TMDU) have uncovered a link between cardiovascular disease and chronic kidney disease, revealing novel disease biomarkers and therapeutic targets ...

Potent, selective ABCC6-targeting positive functional modulator (PFM) improved multiple markers of renal function in animal models of chronic kidney disease (CKD) PFM improved inorganic pyrophosphate ...

The ionic and metabolic impairment observed in chronic kidney disease (CKD) leads to vascular calcification, which can induce cardiovascular events and mortality. Several factors may impact the ...

Restoring ABCC6 function or enhancing its expression offers a new and compelling therapeutic strategy to prevent the progression of CKD towards end-stage renal disease in addition to reducing large ...