Major depression remains a leading contributor to global disability, driving continuous efforts to refine pharmacological treatments. Traditional therapies focus on augmenting monoaminergic ...

Serotonin reuptake inhibitors (SRIs) are a class of drugs that affect the brain’s serotonin system, and doctors most commonly prescribe them as antidepressants. SRIs increase the levels of serotonin ...

The obvious answer has been that it's because they selectively block the reuptake of serotonin. This explanation is appealing because of its simplicity; however, as is so often true of explanations ...

Researchers compared a traditional Chinese medicine, Yueju Pill, with a standard antidepressant and found both reduced depression symptoms. However, only Yueju Pill increased a brain-supporting ...

Neuroscientists recently identified molecular mechanisms in the brain that may explain why the active ingredient (fluoxetine) in selective serotonin reuptake inhibitors (SSRIs) sold under brand names ...

Major depressive disorder (MDD) is a serious mental health condition and is expected to become the most common and costly illness worldwide by 2030. Although treatments for depression have improved, ...