(a) Overgrowth of round cells with eosinophilic cytoplasm in a sheet-like growth pattern. Note the residual teratomatous (glandular) component in the right upper corner. (b) High-power view of the ...

Ionising radiation exerts profound deleterious effects on the male reproductive system, primarily targeting the highly proliferative germinal epithelium within the seminiferous tubules. Exposure leads ...

Phase I trial of chidamide, an oral HDAC inhibitor, in combination with oral etoposide in patients with refractory/recurrent neuroblastoma. Type II RAF inhibitor tovorafenib in relapsed/refractory ...

Testicular germ cell tumors are on the rise in the US. The incidence among Hispanic men now surpasses that of non-Hispanic White men, who have historically had the highest incidence. The incidence of ...

Impact of body mass index (BMI) on clinical and toxicity outcomes in patients with relapsed metastatic germ-cell tumor (GCT) undergoing high-dose chemotherapy (HDCT) with peripheral blood stem cell ...

miR-371a-3p has clinical utility as a marker of residual disease and recurrence in clinical stage 1 testicular germ cell tumor, following orchidectomy. In patients with clinical stage 1 testicular ...

Women with a type of ovarian cancer known as germ cell tumors have a worse prognosis than men with similar tumors, i.e. testicular cancer. After five years with the disease, 98 percent of men were ...

(A) Schematic of the experimental design and analysis. Paracancerous and cancer tissues obtained from surgically resected DLBCLs were split and processed for scRNA-seq and spatial transcriptomics. (B) ...

Mayo Clinic researchers have developed a blood-based method that may help detect germ cell tumors, the most common type of testicular cancer, including cases that do not show up on standard blood ...

Among patients with testicular cancer and paraneoplastic neurologic syndromes (PNS), most developed the neurological symptoms — including ataxia, hearing loss, and vertigo — before their cancer ...