Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.

Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans.

The chirality of tissues and organs is essential for their proper function and development. Tissue-level chirality derives from the chirality of individual cells that comprise the tissue, and cellular ...

Here, we address this question further by combining large-scale electrophysiological recordings, to characterize the functional connectivity of developing neuronal networks in vitro, with a generative ...

A compound found in fungal cell walls can reprogram immune cells in the lungs, potentially worsening inflammation during infections.

The authors provide solid evidence of its utility by benchmarking multiple demultiplexing methods and proposing a new variant consistency metric. While the tool is valuable for guiding method ...

Rats exhibit significant recovery of locomotor function following incomplete spinal cord injuries, albeit with altered gait expression and reduced speed and stepping frequency. These changes likely ...

This important work offers a fresh perspective central to merozoite surface biology and potential implications on vaccine design, challenging the dogma that MSPs are indispensable invasion engines.

Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...