Although early goal-directed therapy (EGDT) has been shown to improve outcomes in severe sepsis and septic shock, clinical implementation has been slow. Barriers such as cost, emergency department ...

Intraoperative individualised goal-directed fluid therapy (GDT) and zero-balance therapy (weight ... besides epidural analgesia in case of laparotomy. Early mobilisation is endorsed by physiotherapist ...

goal-directed treatment of the patient with highly symptomatic (NYHA class III) heart failure. By monitoring trends in pulmonary artery diastolic pressure over time, and adjusting therapy accordingly, ...

Lessons From Taxanes Versus Eribulin for First-Line Metastatic Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer in the EMERALD Study ASCO Guidelines provide recommendations with ...

Cerebellar patients exhibit various motor impairments, but the sequence of primary and compensatory processes leading to these deficits remains unclear. To investigate this, we reversibly blocked ...

The clinical determination of the intravascular volume can be extremely difficult in critically ill and injured patients as well as those undergoing major surgery. This is problematic as fluid ...

Individuals who are higher in conscientiousness, for example, tend to be more organized, attentive to detail, and goal-directed than ... diligently to turn it in early; another person may attempt ...

Patients whose goals of therapy were palliative and those with structural congenital ... we identified systematic delays in delivering critical interventions during early sepsis management in the ED.

Accumulating clinical evidence shows that psychedelic therapy, by synergistically combining psychopharmacology and psychological support, offers a promising transdiagnostic treatment strategy for a ...