The Chicago Cubs and the Minnesota Twins wrap up a 3-game interleague series Thursday at Target Field in Minneapolis.

An eighth-inning go-ahead RBI single from Karter Weber powered the Parkston Mudcats to the victory on Tuesday night. Parkston downed the Lesterville Broncs 5-4 on the road in an interleague game, ...

Interleague play has taken some lustre from the All-Star Game and even the World Series. But it’s now part of baseball’s fabric (Yankees-Dodgers was fun a week and a half ago).

Too bad Interleague play wasn’t part of baseball 60 years ago | Jeff Schudel The Dodgers’ Shohei Ohtani celebrates after scoring on an RBI single by Freddie Freeman during the sixth inning May 26.

Latest Headlines Too bad Interleague play wasn’t part of baseball 60 years ago | Jeff Schudel Subscribers are entitled to 10 gift sharing articles each month.

Interleague play began in 1997 with each team playing 16 games against opponents in the opposite league. This is the third year each team plays 46 interleague games.

The host Chicago Cubs and Oakland Athletics get one last chance to improve on impressive interleague records when they close out a three-game series Wednesday afternoon.

15th anniversary of interleague playHamilton got the first hit, and the Giants beat the Rangers 4-3. This is the 15th anniversary of interleague play's premiere season, and it's the last year of ...

Interleague play will change next year and become even less novel going forward. These are some of the most glorious Brewers interleague moments.

Twenty-five years ago, Major League Baseball needed an image boost and finally experimented with a scheduling change that would launch a new era in the sport.