Objective: To compare the HMPAO SPECT cerebral perfusion patterns in early and late onset Alzheimer’s disease. Methods: Twenty patients with early onset disease (<65 years) and 44 patients with late ...

Wallerian degeneration (WD) after ischaemic stroke is a well known phenomenon following a stereotypical time course. Whereas conventional magnetic resonance imaging fails to detect signal intensity ...

OBJECTIVE Necropsy confirmed clinical diagnostic accuracy for Alzheimer’s disease is claimed to exceed 90%. This figure contains two fallacies; it includes cases in which Alzheimer’s disease exists ...

OBJECTIVE To analyse the natural history and survival of corticobasal degeneration by investigating the clinical features of 14 cases confirmed by postmortem examination. METHODS Patients with ...

Influential models based on an increasing body of neuroimaging evidence propose that insular cortex integrates cognitive, affective, sensory and autonomic information to create a consciously perceived ...

Background: The 39 item Parkinson’s disease questionnaire (PDQ-39) is the most widely used patient reported rating scale in Parkinson’s disease. However, several fundamental measurement assumptions ...

Hashimoto’s encephalopathy is a steroid responsive disorder characterised by high titres of anti-thyroid antibodies and manifesting as sub-acute onset of confusion, episodes of myoclonus, seizures, ...

Background Progression of Parkinson's disease (PD) is characterised by motor deficits which eventually respond less to dopaminergic therapy and thus pose a therapeutic challenge. Deep brain ...

Background: Biomarkers of stroke are an evolving field of clinical research. A serum marker which can differentiate between haemorrhagic and ischaemic stroke in the very early phase would help to ...

Objective To assess the current use of glucocorticoids (GCs) in Duchenne muscular dystrophy in the UK, and compare the benefits and the adverse events of daily versus intermittent prednisolone ...

Background Deep brain stimulation (DBS) improves motor symptoms in Parkinson's disease (PD), but questions remain regarding neuropsychological decrements sometimes associated with this treatment, ...

Objectives/Aims The abuse of nitrous oxide (N2O) may be increasing globally and users and clinicians may not be aware of harms. We highlight these potential harms through the case of a woman treated ...