Blood tests for Alzheimer’s disease are rapidly transforming the way clinicians diagnose the disease. Still, some scientists urge caution when interpreting results, arguing that the meaning of a ...

Rarely do scientists discover a new pathogenic mutation for a sporadic disease. Even less often do they find one that explains half the cases. Pinning disease on a dinucleotide expansion? That’s a new ...

Scientists continue to look for new ways to target sticky amyloid plaques in the brain. The approved immunotherapies have well-known limitations. In the March 5 Science, Marco Colonna and colleagues ...

Circular RNAs are the byproducts of aberrant “backsplicing.” They accumulate and cause problems in the brain with age. According to a study published March 5 in Molecular Cell, ribonuclease κ—an ...

Studies have confirmed the existence of neurogenesis in the adult human brain, but whether newborn neurons bolster cognitive abilities remains controversial. In the February 25 Nature, scientists led ...

Contact Information Ryan Castro, Ph.D. Charlestown, United States Professional Information Postdoctoral Research FellowMassachusetts General Hospital ...

Cerebral small vessel disease is an umbrella term for disorders that cause the brain’s small blood vessels to stiffen, narrow, clog, or leak. cSVD increases a person’s risk for stroke and is a common ...

The notion that lithium might treat Alzheimer’s was revived last year when scientists reported that the brains of people and mice with amyloid pathology are deficient in the metal ion, and that the ...

The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. Missense mutations in PSEN2 are a rare cause of early onset Alzheimer's disease.

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

Professional Information University of South Florida Comments Could Tau Explain the Link Between Pneumonia and Dementia? 06 Mar 2026 ...

The network provides high-quality brain tissue to scientists and clinicians and supports major initiatives on research into neurological disorders, including the aims of the Ministerial Action Group ...