RMD Open

Autoantibody biomarkers and first-line therapy response in RA: findings from the CAP48 cohort

Objective A panel of antibodies against three antigens, University Hasselt (UH)-rheumatoid arthritis (RA).305, 318 and 329, has been associated with lack of response to first-line therapy in the Care ...
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Association between SARC-F as a self-report screening tool for sarcopenia and muscle strength, physical performance, daily activity, patient-reported outcomes and body ...

Background This study aimed to explore the association of the sarcopenia questionnaire Strength, Assistance with walking, Rise from a chair, Climb stairs, Falls (SARC-F) with muscle strength, physical ...
rmdopen.bmj

Hyposplenism in systemic lupus erythematosus: biological and radiological characteristics and its association with increased risk of infection

Objective This study aimed to evaluate the prevalence of hyposplenism in patients with systemic lupus erythematosus (SLE) and its association with an increased risk of infection. Methods This ...
rmdopen.bmj

Mortality incidence in spondyloarthritis: real-world evidence using the TriNetX Global Collaborative Network

Objective To assess all-cause mortality in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and to examine the influence of sex, comorbidities and biologic or targeted ...
RMD Open

Cellular and molecular basis of neuropathic pain

Neuropathic pain is a devastating type of pain that significantly reduces the quality of life of affected people.
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Bimekizumab longer-term safety profile in adult patients with axial spondyloarthritis or psoriatic arthritis: an updated analysis of six phase IIb/III clinical studies

Objective To present updated integrated safety analyses of bimekizumab in patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA). Methods Safety data pooled from six phase IIb/III ...
rmdopen.bmj

2016 sJIA-MAS criteria and a step-up therapeutic approach in KD-MAS: insights from a combined cohort and literature review

Objectives To describe diagnostic framework classification, treatment patterns and outcomes in Kawasaki disease-associated macrophage activation syndrome (KD-MAS) using a single-centre cohort and a ...
rmdopen.bmj

Inflammation response criteria for rheumatoid arthritis based on the two-component disease activity score

Objectives To develop response criteria for rheumatoid arthritis (RA) using the two-component Disease Activity Score in 28 joints (2C-DAS28). Methods Data were available for three stages of RA ...
rmdopen.bmj

Clinical phenotype and long-term damage in paediatric Behçet’s disease: comparative performance of ISG, ICBD and PEDBD classification criteria in a retrospective endemic cohort

Objectives To compare the sensitivity of International Study Group (ISG, 1990), International Criteria for Behçet’s Disease (ICBD, 2014) and the Paediatric Behçet’s Disease (PEDBD, 2016) ...
RMD Open

Bone properties and biomechanics in patients with psoriatic disease: a cross-sectional study with high-resolution peripheral quantitative CT (HRpQCT)

Background Psoriatic disease has a complex effect on bone metabolism, resulting in both pathological bone formation and bone resorption. However, microstructural changes in cortical and trabecular ...
RMD Open

Head and neck cancer risk in patients with rheumatoid arthritis compared with matched controls: a nationwide cohort study

Objective Autoimmune rheumatic diseases, including rheumatoid arthritis (RA), have recently been associated with an increased risk of cancer, particularly head and neck cancer (HNC). This study aimed ...
RMD Open

Distinct pattern of comorbidities hinders treatment target attainment in SLE through persistent disease activity and delayed glucocorticoid tapering: longitudinal data fro…

Background Remission and low-disease activity are recommended targets in systemic lupus erythematosus (SLE), yet many ...