Revised 3.2. Measurement of TC, LDL-C, HDL-C, TG, and Non–HDL-C COR 2a: For adults with an LDL-C level <70 mg/dL (<1.8 mmol/L), measurement of direct LDL-C or modified LDL-C estimate is reasonable to ...

VESALIUS-CV is a large (N=12 257), rigorously conducted, international, randomized, placebo-controlled trial conducted in patients at high cardiovascular risk but without prior myocardial infarction ...

eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are ...

Circulation: Population Health and Outcomes, a journal of the American Heart Association, invites applications for an Associate Editor to join the journal’s new editorial team led by incoming ...

BACKGROUND: Peripheral artery disease (PAD) and its severe form, chronic limb-threatening ischemia (CLTI), significantly impair blood flow to the lower extremities, affecting millions of adults ...

BACKGROUND: Aortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification ...

BACKGROUND: Consensus-based clinical practice guidelines recommend echocardiographic surveillance intervals based on aortic stenosis (AS) severity; however, real-world surveillance practices and ...

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality globally. Low-density lipoprotein cholesterol is a causal risk factor for atherosclerotic cardiovascular ...

BACKGROUND: There is limited evidence of the relationship between aortic and iliac calcification and aortic events (aortic dissection or aneurysm rupture) and major adverse limb events (MALEs; ...

eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language.

BACKGROUND: Forecasts for the future prevalence of cardiovascular disease and stroke are crucial to guide efforts to improve health outcomes across the life course for women. METHODS: Using historical ...

Background: Chronic insomnia affects up to one-third of adults, and over-the-counter melatonin is increasingly promoted as a “cardiometabolic-friendly” sleep aid. Robust data on its long-term ...