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Malignant hyperthermia is a rare, inherited disorder of skeletal muscle Triggered by volatile anesthetics or succinylcholine, a mutated RYR1 calcium channel stays open, flooding the cytoplasm with calcium This sustained calcium release drives nonstop actin-myosin cross-bridging, rapid ATP depletion, and massive heat production Uncontrolled hypermetabolism leads to rigidity, hyperthermia, acidosis, and rhabdomyolysis within minutes #MalignantHyperthermia #Anesthesia #RYR1 #MedTok #Anesthesiology
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